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Volume 82, Issue 1
Received, 14th June, 2010, Accepted, 12th July, 2010, Published online, 13th July, 2010. |
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| [2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with α,ω-Diynes |
Stanislav Opekar, Pavel Turek, Radek Pohl, Blanka Klepetářová, Ivan Votruba, Michal Hocek,* and Martin Kotora*
Department of Organic and Nuclear Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43 Praha 2, Czech Republic |
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Abstract
6-Alkynyl-7-benzylpurines were prepared by the Sonogashira reaction from 6-chloro-7-benzylpurines and terminal alkynes. The prepared alkynylpurines were cyclotrimerized with various 1,6-diynes in the presence of Ni(cod)2/2PPh3 catalytic system into the corresponding 6-aryl-7-benzylpurines under ambient conditions. The prepared 6-alkynyl- and 6-aryl-7-benzylpurines were tested for cytostatic activity. |
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Graphical Abstract
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| Corresponding author; email: kotora@natur.cuni.cz |
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