|
|
Volume 48, Issue 11 ( November, 1, 1998 ), Pages 2279-2285
Received, 14th July, 1998, Accepted, 21st August, 1998, Published online, 1st January, 1970.
DOI: 10.3987/COM-98-8293 |
| PDF (198KB) |
|
Synthesis of Praziquantel via N-Acyliminium Ion Cyclization of Amido Acetals through Several Synthetic Routes
|
Joong Hyup Kim, Yong Sup Lee, and Choong Sup Kim*
Division of Applied Science, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea
|
|
Abstract
Syntheses of praziquantel have been accomplished via an N-acyliminium ion by several routes including the tandem nucleophilic addition-cyclization sequence from amido acetal (8) or (10) and a stepwise cyclization of enamide (9) generated from the nucleophilic addition reaction of amido acetal (8) or (10).
|
|
Graphical Abstract
 |
|
| Corresponding author; email: |
|
|
