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Volume 55, Issue 9 ( September, 1, 2001 ), Pages 1747-1757
Received, 26th June, 2001, Accepted, 6th August, 2001, Published online, 1st January, 1970.
DOI: 10.3987/COM-01-9283 |
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One Pot Synthesis of Fused Pyrimidines from 2-[N-(Methylthiothiocarbonyl)amino]acetate
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A. Z. M. Shaifullah Chowdhury,* Yasuyuki Shibata, Masatoshi Morita, Kunimitsu Kaya, and Tomoharu Sano
National Institute for Environmental Studies, Environmental Chemistry Division, 16-2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan
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Abstract
A variety of 3-substituted fused pyrimidines (4a-k) are readily obtained from the 2-amino esters (2a-k) with 2-[N-(methylthiothiocarbonyl)-amino]acetate (1). Condensed imidazo[1,2-c]pyrimidine ring system was also constructed in a one-pot process by reacting heteroaromatic 2-amino nitriles (3a-l) with 1, obtaining a number of novel tri- and tetracyclic compounds (5a-l).
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Graphical Abstract
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Keywords
1. Heterocondensed Pyrimidine
2. 3-Substituted Pyrimidine
3. Dithiocarbamate Reagent
4. 2-Amino Ester and 2-Amino Nitrile
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| Corresponding author; email: a.chowdhury@nies.go.jp |
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