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Abstract

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Review | Special issue | Vol 42, No. 2, 1996, pp.901-909
Published online:
DOI: 10.3987/REV-95-SR4
Chemical Identification of Binding Sites for Calcium Channel Antagonists

Hitoshi Nakayama and Yuichi Kanaoka

*Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan

Abstract

Binding sites of three typical calcium channel antagonists including heterocyclic 1,4-dihydropyridine and benzothiazepines, and phenylalkylamines, have been identified within the primary structures of calcium channels by photoaffinity labeling technique. We briefly review the results and discuss the future prospect.

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