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Paper | Special issue | Vol 77, No. 2, 2009, pp.1219-1234
Published online: 25th September, 2008
DOI: 10.3987/COM-08-S(F)103
Total Synthesis of (±)-Morphine

Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan, and Tohru Fukuyama*

*Laboratory of Synthetic Organic & Medicinal Chemistry, Schol of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan

Abstract

The morphinan skeleton was effectively synthesized by an intramolecular Mannich-type reaction. Further transformation led to the total synthesis of morphine.

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