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Short Paper | Regular issue | Vol 87, No. 10, 2013, pp.2081-2091
Published online, 22nd August, 2013
DOI: 10.3987/COM-13-12793
EFFICIENT SYNTHESIS OF PURINE DERIVATIVES BY ONE-POT THREE-COMPONENT MANNICH TYPE REACTION

Qian Zhang,* Bai-Wei Ma, Yong-Zhen Huang, Qian-Qian Wang, Xing-Xing Wang, Gui-Rong Qu, and Hai-Ming Guo*

*School of Chemical and Chemical Engineering, Henan Normal University, 46# East of Construction Road, Xinxiang, Henan 453007, China

Abstract

An efficient, facile three-component Mannich-type reaction on purine rings was described. This reaction proceeded smoothly under the catalysis of ethylenediamine at ambient temperature in high regioselectivities with exclusive N9-alkylated products. A wide range of purine derivatives were obtained in high yields.