Heterocycles Database
Natural Products with
Heterocyclic Ring System
 
 1975-2014
 58,387 Compounds
 25 April, 2012
 
Search by:
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Group

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Carbon
Molecular Weight
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Group

Molecular Fomula:

Molecular Weight:

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Author
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Journal
Year
 
 Nomenclature :
 
The natural products are listed under the name used in the original literature.
 
 The abbreviations :
 
The following abbreviations have been used :
 
act : biological activity
cd : circular dichroism
Cnmr : 13C-nuclear magnetic resonance spectrum
Hnmr : 1H-nuclear magnetic resonance spectrum
ir : infrared spectrum
mass : mass spectrum
syn : total synthesis
uv : ultraviolet spectrum
 
 Journals :
 
This database lists the natural products with heterocyclic ring system whose structure has been determined since 1975.
The journals which have been covered are as follows.
 
Angew. Chem. Int. Ed. Engl.
Angew. Chem. Int. Ed.
Bull. Chem. Soc. Japan
Chem. and Ind.
Chem. Ber.
J. Chem. Soc., Chem. Commun.
Chem. Commun.
Chem. Eur. J.
Chemistry Lett.
Chem. Pharm. Bull.
Coll. Czech. Chem. Commun.
Eur. J. Inorg. Chem.
Eur. J. Org. Chem.
Experientia
Helv. Chim. Acta
Heterocycles
J. Am. Chem. Soc.
J. Antibiot.
J. Chem. Soc., Perkin Trans. 1
J. Heterocycl. Chem.
J. Med. Chem.
J. Nat. Prod.
J. Org. Chem.
J. Pharm. Sci.
Liebigs Ann. Chem.
Monatsh. Chem.
Org. Lett.
Phytochemistry
Planta medica
Synlett
Synth. Commun.
Synthesis
Tetrahedron
Tetrahedron Asymmetry
Tetrahedron Lett.
Yakugaku Zasshi
 
 Editor :
 
Editor
Keiichiro Fukumoto

Associate Editor
Kunio Ogasawara
Yoshiharu Iwabuchi

Assistant Editors
Naoki Kanoh
Muneo Kawasumi
Takashi Moriya
Keiichi Murakami
Kohei Sakanishi
Yusuke Sasano
Takuro Shibuta
Masatoshi Shibuya

Editorial Assistants
Sayaka Kametani
Kishiko Nakano
Yuki Shima
Kazuko Todoroki
Michi Yamamoto
 New Heterocyclic Natural Products
This journal will list the new natural products with a heterocyclic ring system, collected from current chemical literature, whose structure has been established.
 
25 April, 2012
Search by Group:
Polyketides
Aromatics
Terpenes
Steroids
Alkaloids
Antibiotics
Miscellaneous
 
All
 
Search by Journal :
Vol.
No.
Chem. Pharm. Bull.
59
9
Eur. J. Org. Chem.
26
Helv. Chim. Acta
94
9
Heterocycles
83
9
J. Med. Chem.
54
17
J. Nat. Prod.
74
9
Org. Lett.
13
17, 18
Planta medica
77
13, 14
Tetrahedron
67
35, 36, 37, 38, 39
Tetrahedron Lett.
52
36, 39
  242 data found. 1 - 30 listed Next Last   

Polyketides
Clerobungin A
C10H14O4 = 198
Tetrahedron Lett.    2014, 55 , 2277
H. Zhu, L. Huan, C. Chen, J. Yang, J. He, Y. Chen, G. Yao, Z. Luo, Y. Xue, Y. Zhang
DOI: 10.1016/j.tetlet.2014.02.088
CrossRef
 
[NS]  Clerodendrum bungei
[mp]
[bp]
[α]D      + 36.2°     [ CHCl3 ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]
Notes:a pair of enantiomers

Polyketides
Xylogiblactone B
C9H14O5 = 202
J. Nat. Prod.    2014, 77 , 751
Y.-C. Chang, C.-K. Lu, Y.-R. Chiang, G.-J. Wang, Y.-M. Ju, Y.-H. Kuo, T.-H Lee
DOI: 10.1021/np400523k
CrossRef
 
[NS]  Xylotumulus gibbisporus YMJ863
[mp]
[bp]
[α]D      + 78.9°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Polyketides
Xylogiblactone C
C10H16O5 = 216
J. Nat. Prod.    2014, 77 , 751
Y.-C. Chang, C.-K. Lu, Y.-R. Chiang, G.-J. Wang, Y.-M. Ju, Y.-H. Kuo, T.-H Lee
DOI: 10.1021/np400523k
CrossRef
 
[NS]  Xylotumulus gibbisporus YMJ863
[mp]
[bp]
[α]D      + 94.5°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Polyketides
Xylogiblactone A
C9H13O4Cl = 220.5
J. Nat. Prod.    2014, 77 , 751
Y.-C. Chang, C.-K. Lu, Y.-R. Chiang, G.-J. Wang, Y.-M. Ju, Y.-H. Kuo, T.-H Lee
DOI: 10.1021/np400523k
CrossRef
 
[NS]  Xylotumulus gibbisporus YMJ863
[mp]
[bp]
[α]D      + 62.1°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Polyketides
Ivorenolide B
C18H24O4 = 304
Org. Lett.    2014, 16 , 2062
Y. Wang, Q.-F. Liu, J.-J. Xue, Y. Zhou, H.-C. Yu, S.-P. Yang, B. Zhang, J.-P. Zuo, Y. Li, J.-M. Yue
DOI: 10.1021/ol500667d
CrossRef
 
[NS]  Khaya ivorensis
[mp]
[bp]
[α]D      - 13.0°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]immunosuppressive activity

Polyketides
Mangiferaelactone
C20H32O8 = 400
Tetrahedron Lett.    2014, 55 , 2642
H. E. Ortega, Y. Y. Shen, K. TenDyke, N. Ríos, L. Cubilla-Ríos
DOI: 10.1016/j.tetlet.2014.03.012
CrossRef
 
[NS]  Pestalotiopsis mangiferae
[mp]
[bp]
[α]D      – 1.7°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]antibacterial activity

Polyketides
Omaezallene
C15H19O3Br3 = 487
Angew. Chem. Int. Ed.    2014, 53 , 3909
T. Umezawa, Y. Oguri, H. Matsuura, S. Yamazaki, M. Suzuki, E. Yoshimura, T. Furuta, Y. Nogata, Y. Serisawa, K. Matsuyama-Serisawa, T. Abe, F. Matsuda, M. Suzuki, T. Okino
DOI: 10.1002/anie.201311175
CrossRef
 
[NS]  Laurencia species
[mp]
[bp]
[α]D      - 127°     [ CHCl3 ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]antifouling activity, ecotoxicity

Polyketides
Omaezallene, 12Z-
C15H19O3Br3 = 487
Angew. Chem. Int. Ed.    2014, 53 , 3909
T. Umezawa, Y. Oguri, H. Matsuura, S. Yamazaki, M. Suzuki, E. Yoshimura, T. Furuta, Y. Nogata, Y. Serisawa, K. Matsuyama-Serisawa, T. Abe, F. Matsuda, M. Suzuki, T. Okino
DOI: 10.1002/anie.201311175
CrossRef
 
[NS]  Laurencia species
[mp]
[bp]
[α]D      - 44.3°     [ CHCl3 ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]antifouling activity

Polyketides
Omaezallene, Dihydro-
C15H21O3Br3 = 489
Angew. Chem. Int. Ed.    2014, 53 , 3909
T. Umezawa, Y. Oguri, H. Matsuura, S. Yamazaki, M. Suzuki, E. Yoshimura, T. Furuta, Y. Nogata, Y. Serisawa, K. Matsuyama-Serisawa, T. Abe, F. Matsuda, M. Suzuki, T. Okino
DOI: 10.1002/anie.201311175
CrossRef
 
[NS]  Laurencia species
[mp]
[bp]
[α]D      - 39.0°     [ CHCl3 ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]antifouling activity

Polyketides
Campechic Acid B
C36H62O8 = 622
J. Nat. Prod.    2014, 77 , 976
L. Yu, M. E. Trujillo, S. Miyanaga, I. Saiki, Y. Igarashi
DOI: 10.1021/np401071x
CrossRef
 
[NS]  Streptomyces species
[mp]
[bp]
[α]D      + 0.9°     [ CHCl3 ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]cytotoxicity

Polyketides
Campechic Acid A
C37H64O8 = 636
J. Nat. Prod.    2014, 77 , 976
L. Yu, M. E. Trujillo, S. Miyanaga, I. Saiki, Y. Igarashi
DOI: 10.1021/np401071x
CrossRef
 
[NS]  Streptomyces species
[mp]
[bp]
[α]D      - 10.5°     [ CHCl3 ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]cytotoxicity

Aromatics
Gymnothedelignan A
C15H16O5 = 276
Tetrahedron Lett.    2014, 55 , 2869
S.-J. Xiao, X.-X. Lei, B. Xia, H.-P. Xiao, D.-H. He, D.-M. Fang, H.-Y. Qi, F. Chen, L.-S. Ding, Y. Zhou
DOI: 10.1016/j.tetlet.2014.03.091
CrossRef
 
[NS]  Gymnotheca chinensis
[mp]
[bp]
[α]D      – 214°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Aromatics
Gymnothedelignan B
C16H20O5 = 292
Tetrahedron Lett.    2014, 55 , 2869
S.-J. Xiao, X.-X. Lei, B. Xia, H.-P. Xiao, D.-H. He, D.-M. Fang, H.-Y. Qi, F. Chen, L.-S. Ding, Y. Zhou
DOI: 10.1016/j.tetlet.2014.03.091
CrossRef
 
[NS]  Gymnotheca chinensis
[mp]
[bp]
[α]D      – 180°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Aromatics
Peniphenone D
C15H16O6 = 292
J. Nat. Prod.    2014, 77 , 800
H. Li, J. Jiang, Z. Liu, S. Lin, G. Xia, X. Xia, B. Ding, L. He, Y. Lu, Z. She
DOI: 10.1021/np400880w
CrossRef
 
[NS]  Penicillium dipodomyicola HN4-3A
[mp]127 - 128 ℃
[bp]
[α]D      - 72°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Aromatics
Toddalolactone, ent-
C16H20O6 = 308
J. Nat. Prod.    2014, 77 , 955
T.-T. Lin, Y.-Y. Huang, G.-H. Tang, Z.-B. Cheng, X. Liu, H.-B. Luo, S. Yin
DOI: 10.1021/np401040d
CrossRef
 
[NS]  Toddalia asiatica
[mp]
[bp]
[α]D      - 69°     [ CHCl3 ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Aromatics
Nigrospin C
C18H26O5 = 322
Tetrahedron Lett.    2014, 55 , 2749
J.-J. Dong, J. Bao, X.-Y. Zhang, X.-Y. Xu, X.-H. Nong, S.-H. Qi
DOI: 10.1016/j.tetlet.2014.03.060
CrossRef
 
[NS]  Nigrospora oryzae SCSGAF 0111
[mp]
[bp]
[α]D      + 59.0°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Aromatics
Spiromastixone A
C19H20O5 = 328
J. Nat. Prod.    2014, 77 , 1021
S. Niu, D. Liu, X. Hu, P. Proksch, Z. Shao, W. Lin
DOI: 10.1021/np5000457
CrossRef
 
[NS]  Spiromastix species
[mp]
[bp]
[α]D      + 36°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]inhibitory activity against the Gram-positive bacteria

Aromatics
Peniphenone A
C19H24O5 = 332
J. Nat. Prod.    2014, 77 , 800
H. Li, J. Jiang, Z. Liu, S. Lin, G. Xia, X. Xia, B. Ding, L. He, Y. Lu, Z. She
DOI: 10.1021/np400880w
CrossRef
 
[NS]  Penicillium dipodomyicola HN4-3A
[mp]161 - 163 ℃
[bp]
[α]D      0°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Aromatics
Nigrospin B
C19H24O6 = 348
Tetrahedron Lett.    2014, 55 , 2749
J.-J. Dong, J. Bao, X.-Y. Zhang, X.-Y. Xu, X.-H. Nong, S.-H. Qi
DOI: 10.1016/j.tetlet.2014.03.060
CrossRef
 
[NS]  Nigrospora oryzae SCSGAF 0111
[mp]
[bp]
[α]D      + 62.0°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

Aromatics
Rubrolide R
C22H20O4 = 348
J. Antibiot.    2014, 67 , 315
T. Zhu, Z. Chen, P. Liu, Y. Wang, Z. Xin, W. Zhu
DOI: 10.1038/ja.2013.135
CrossRef
 
[NS]  Aspergillus terreus OUCMDZ-1925
[mp]202-203 ℃
[bp]
[α]D
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]antioxidation, cytotoxic

Aromatics
Rubrolide S
C22H20O4 = 348
J. Antibiot.    2014, 67 , 315
T. Zhu, Z. Chen, P. Liu, Y. Wang, Z. Xin, W. Zhu
DOI: 10.1038/ja.2013.135
CrossRef
 
[NS]  Aspergillus terreus OUCMDZ-1925
[mp]
[bp]
[α]D
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]antivirus activirty, cytotoxic

Aromatics
Polyozellic Acid
C18H8O8 = 352
J. Nat. Prod.    2014, 77 , 963
I. Nagasawa, A. Kaneko, T. Suzuki, K. Nishio, K. Kinoshita, M. Shiro, K. Koyama
DOI: 10.1021/np401046z
CrossRef
 
[NS]  Polyozellus multiplex
[mp]> 250 ℃
[bp]
[α]D
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]HUVECs growth inhibitory activity

Aromatics
Spiromastixone B
C19H19O5Cl = 362.5
J. Nat. Prod.    2014, 77 , 1021
S. Niu, D. Liu, X. Hu, P. Proksch, Z. Shao, W. Lin
DOI: 10.1021/np5000457
CrossRef
 
[NS]  Spiromastix species
[mp]
[bp]
[α]D      + 18°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]inhibitory activity against the Gram-positive bacteria

Aromatics
Spiromastixone C
C19H19O5Cl = 362.5
J. Nat. Prod.    2014, 77 , 1021
S. Niu, D. Liu, X. Hu, P. Proksch, Z. Shao, W. Lin
DOI: 10.1021/np5000457
CrossRef
 
[NS]  Spiromastix species
[mp]
[bp]
[α]D      + 22°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]inhibitory activity against the Gram-positive bacteria

Aromatics
Spiromastixone D
C19H19O5Cl = 362.5
J. Nat. Prod.    2014, 77 , 1021
S. Niu, D. Liu, X. Hu, P. Proksch, Z. Shao, W. Lin
DOI: 10.1021/np5000457
CrossRef
 
[NS]  Spiromastix species
[mp]
[bp]
[α]D      + 45°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]inhibitory activity against the Gram-positive bacteria

Aromatics
Balsacone D
C24H22O5 = 390
Phytochemistry    2014, 100 , 141
F. Simard, J. Legault, S. Lavoie, A. Pichette
DOI: 10.1016/j.phytochem.2013.12.018
CrossRef
 
[NS]  Populus balsamifera
[mp]186 - 188 ℃
[bp]
[α]D      (1)°     [ acetone ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]antibacterial activity
Notes:(1) (-): - 17.4, (+): + 15.5
(2) (-)-enantiomer

Aromatics
Spiromastixone E
C19H18O5Cl2 = 397
J. Nat. Prod.    2014, 77 , 1021
S. Niu, D. Liu, X. Hu, P. Proksch, Z. Shao, W. Lin
DOI: 10.1021/np5000457
CrossRef
 
[NS]  Spiromastix species
[mp]
[bp]
[α]D      + 18°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]inhibitory activity against the Gram-positive bacteria

Aromatics
Spiromastixone M
C19H18O5Cl2 = 397
J. Nat. Prod.    2014, 77 , 1021
S. Niu, D. Liu, X. Hu, P. Proksch, Z. Shao, W. Lin
DOI: 10.1021/np5000457
CrossRef
 
[NS]  Spiromastix species
[mp]
[bp]
[α]D      + 43°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]inhibitory activity against the Gram-positive bacteria

Aromatics
Peniphenone B
C21H18O8 = 398
J. Nat. Prod.    2014, 77 , 800
H. Li, J. Jiang, Z. Liu, S. Lin, G. Xia, X. Xia, B. Ding, L. He, Y. Lu, Z. She
DOI: 10.1021/np400880w
CrossRef
 
[NS]  Penicillium dipodomyicola HN4-3A
[mp]223- 224 ℃
[bp]
[α]D
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]inhibitory activityvagainst MptpB

Aromatics
Gymnothelignan P
C22H26O7 = 402
Helv. Chim. Acta    2014, 97 , 499
S. Xiao, D. He, D. Fang, F. Chen, L. Ding, Y. Zhou
DOI: 10.1002/hlca.201300208
CrossRef
 
[NS]  Gymnotheca chinensis
[mp]
[bp]
[α]D      – 90°     [ MeOH ]
[Ph]
uv Hnmr Cnmr ir
Xray mass cd syn
[act]

  242 data found. 1 - 30 listed Next Last   
   
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