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Note | Regular issue | Vol 57, No. 9, 2002, pp. 1653 - 1658
Published online:
DOI: 10.3987/COM-02-9518
Amides from the Seeds of Piper nigrum Linn. and Their Insecticidal Activity

Bina S. Siddiqui,* Tahsin Gulzar, and Sabira Begum

*H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan

Abstract

Two new amides pipertipine (1) and pipercitine (2) have been isolated from the dried seeds of Piper nigrum along with eight known constituents of β-sitosterol, (2E, 4E, 8Z)-N-isobutyleicosatrienamide, pellitorine, guineensine, piperine, piperettine, pipericine, and (3,4-methylenedioxyphenyl)cinnamaldehyde. The structures of 1 and 2 have been elucidated as 1-[8-(3′, 4′-methylenedioxyphenyl)-(7E)-octaenoyl]piperidine and 1-[(2E)-octadecenoyl]piperidine, through extensive spectral studies including 2D NMR. New compounds 1 and 2 and most of the known exhibited toxicity against fourth- instar larvae of Aedes aegypti.

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