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Paper | Regular issue | Vol 75, No. 2, 2008, pp. 339 - 356
Published online: 23rd October, 2007
DOI: 10.3987/COM-07-11219
Synthesis of in vivo Metabolites of the New Adenosine A3 Receptor PET-Radiotracer [18F]FE@SUPPY

Karem Shanab,* Wolfgang Wadsak, Leonhard-Key Mien, Markus Mitterhauser, Wolfgang Holzer, Victoria Polster, Helmut Viernstein, and Helmut Spreitzer*

*Department of Drug and Natural Product Synthesis, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria

Abstract

The synthesis of three expected metabolites of the new adenosine A3 receptor PET-radiotracer [18F]FE@SUPPY is described. The target compounds - all pentasubstituted pyridines - were obtained via Hantzsch type synthesis of appropriate 1,4-dihydropyridines, followed by oxidation to the corresponding pyridines and subsequent modifications of the ester moieties.

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