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Abstract

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Note | Special issue | Vol 74, No. 1, 2007, pp. 999 - 1008
Published online: 2nd November, 2007
DOI: 10.3987/COM-07-S(W)66
Synthesis of a Cyclic Guanidine Hemiaminal Pertinent to the Axinellamines

Liang Tang and Daniel Romo*

*Department of Chemistry, Texas A & M University, College Station, Texas 77843-3255, U.S.A.

Abstract

Potential methods for the generation of the cyclic guanidine hemiaminal functionality of axinellamine A (1) from a hydantoin precursor are examined. An activation-reduction sequence was developed for the reduction of cyclic acyl guanidines.

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