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Abstract

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Paper | Regular issue | Vol 27, No. 10, 1988, pp. 2443 - 2457
Published online:
DOI: 10.3987/COM-88-4681
Pyrazoles 3. N-1 Protected 4-Substituted Pyrazoles — Synthesis and Nmr Investigation

Gottfried Heinisch and Wolfgang Holzer*

*Institute of Pharmaceutical Chemistry, University of Vienna, Währinger Strasse 10, A-1090 Vienna, Austria

Abstract

13C-Nmr Data (chemical shifts, substituent chemical shifts (SCS), coupling constants) are reported for 26 1,4-disubstituted pyrazoles, bearing a benzyl, benzoyl or (substituted) benzenesulfonyl protecting group at N-1. The pyrazole derivatives 8a-d were prepared from the corresponding NH-pyrazoles. In the synthesis of compounds 2-5 l-benzyl-4-pyrazolecarbaldehyde served as the starting material.

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