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Abstract

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Paper | Special issue | Vol 35, No. 2, 1993, pp. 843 - 850
Published online:
DOI: 10.3987/COM-92-S(T)66
α-Amino Ketones from Amino Acids as Precursors for the Knorr Pyrrole Synthesis

James M. Hamby* and John C. Hodges

*Parke-Davis Pharmaceutical research, Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48015-2430, U.S.A.

Abstract

A useful and versatile modification of the Knorr pyrrole synthesis is described. Key α-amino ketone intermediates for the Knorr condensation were readily prepared from the N-methoxy-N-methylamides of amino acids and condensed with 1,3-dicarbonyl compounds to afford tetrasubstituted pyrroles in good yields.

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