e-Journal

Abstract

1 data found. 1 - 1 listed
Paper | Regular issue | Vol 41, No. 10, 1995, pp. 2279 - 2287
Published online:
DOI: 10.3987/COM-95-7177
A New Synthesis of 3-Substituted Indolines and Indoles

Masaru Kihara,* Yasumasa Iwai, and Yoshimitsu Nagao

*Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770, Japan

Abstract

3-Phenyl- and 3-alkyl-3-hydroxyindolines were synthesized by intramolecular Barbier reaction of phenyl and alkyl N-(2-iodophenyl)-N-methylaminomethyl ketones with n-BuLi, which were easily prepared from N-methyl-2-iodoaniline and bromomethyl ketones. The treatment of the indolines with acid gave the corresponding indoles in quantitative yields.

PDF (258KB)
1 data found. 1 - 1 listed