e-Journal

Abstract

1 data found. 1 - 1 listed
Communication | Regular issue | Vol 2, No. 5, 1974, pp. 589 - 593
Published online:
DOI: 10.3987/R-1974-05-0589
A Novel Reaction of 6-Nitroquinoline with Active Methylene Compounds in the Presence of Potassium Cyanide

Yukihiko Tomioka, Akihumi Mochiike, Junko Himeno, and Motoyoshi Yamazaki*

*Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan

Abstract

6-Nitroquinoline (I) reacts with ethyl cyanoacetate in the presence of potassium cyanide or sodium hydride to produce 6-ethoxalylaminoquinoline-5-carbonitrile (IIa) and diethyl 2-cyano-3-(5-cyano-6-quinolylamino)fumalate (III). Reactions with some other active methylene compounds in the presence of potassium cyanide also afforded respective products corresponding to IIs (IIb, IIc and IId).

PDF (89KB)
1 data found. 1 - 1 listed