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Report | Regular issue | Vol 20, No. 10, 1983, pp. 2035 - 2037
Published online:
DOI: 10.3987/R-1983-10-2035
Synthesis of 2-Substituted 3,5-Dibromothiophenes through Base-catalyzed Halogen Dance Reaction of 2,5-Dibromothiophene

Shinzo Kano, Yoko Yuasa, Tsutomu Yokomatsu, and Shiroshi Shibuya

*School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

Treatment of 2,5-dibromothiophene with LDA in THF at -78 °C, followed by quenching with electrophiles afforded the corresponding 2-substituted 3,5-dibromothiophenes in good yield.

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