1 data found. 1 - 1 listed
Communication | Special issue | Vol 80, No. 2, 2010, pp. 831 - 840
Published online: 10th September, 2009
DOI: 10.3987/COM-09-S(S)99
Nucleophilic Addition of Hetaryllithium Compounds to 3-Nitro-1-(phenylsulfonyl)indole: Synthesis of Tetracyclic Thieno[3,2-c]-δ-carbolines

Philip E. Alford, Tara L. S. Kishbaugh, and Gordon W. Gribble*

*Department of Chemistry, Dartmouth College, 6128 Burke Laboratory, Hanover,
New Hampshire 03755, U.S.A.


3-Nitro-1-(phenylsulfonyl)indole undergoes addition of aryl- and hetaryllithium nucleophiles to produce 2-substituted-3-nitroindoles. Mild reductive–acylation provides excellent access to 3-amido-2-hetarylindoles from which new thieno[3,2-c]-δ-carbolines are synthesized by cyclodehydration.

Full Text HTMLPDF (1.1MB)PDF with Links (1MB)
1 data found. 1 - 1 listed