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Abstract

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Paper | Special issue | Vol 80, No. 2, 2010, pp. 941 - 956
Published online: 7th September, 2009
DOI: 10.3987/COM-09-S(S)61
A Simple and Convenient High Yielding Synthesis of Substituted Isoindolines

Keith Smith,* Gamal A. El-Hiti, Amany S. Hegazy, and Ahmed Fekri

*School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, U.K.

Abstract

Trifluoroacetic anhydride-induced dehydration of substituted 2-(pivaloylaminomethyl)phenyl- and 2-(dimethylaminocarbonylmethyl)phenylmethanols gives the corresponding isoindolines in excellent yields when there are aryl substituents at the methanol carbon atom.

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