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Abstract

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Paper | Special issue | Vol 84, No. 1, 2012, pp. 615 - 623
Published online: 5th August, 2011
DOI: 10.3987/COM-11-S(P)32
Synthesis of Nalbuphine from Oripavine via N-Demethylation of N-Cyclobutylmethyl Oripavine

Ales Machara, D. Phillip Cox, and Tomas Hudlicky*

*Department of Chemistry, Brock University, St. Catharines, Ontario, L2S 3A1, Canada

Abstract

A short synthesis of nalbuphine from oripavine is reported via N-demethylation of N-cyclobutylmethyloripavine ammonium bromide.

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