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Paper | Regular issue | Vol 87, No. 12, 2013, pp. 2513 - 2532
Published online: 21st October, 2013
DOI: 10.3987/COM-13-12836
SYNTHESIS AND BIOLOGICAL EVALUATIONS OF A SERIES OF NOVEL AZOLYL, AZINYL, PYRANYL, CHROMONYL AND AZEPINYL PHOSPHONATES

Tarik E. Ali,* Salah A. Abdel-Aziz, Somaya M. El-Edfawy, El-Hossain A. Mohamed, and Somaia M. Abdel-Kariem

*Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo 11711, Egypt

Abstract

facile synthetic methodology of novel azolyl, azinyl and azepinyl phosphonates as cyclic α-aminophosphonates was described. Chromonyl α-aminophosphonates, γ-pyranyl and γ-pyridinyl phosphonates were also prepared. The methodology depends on reaction of 6-methyl-3-formylchromone, nitrogen and carbon nucleophiles in the presence of diethyl phosphite in one-pot three component under solvent-free conditions. The products were evaluated for their antimicrobial activities and antioxidant properties.

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