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An International Journal for Reviews and Communications in Heterocyclic ChemistryWeb Edition ISSN: 1881-0942
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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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December 24, 2019
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e-Journal
Abstract
1 data found. 1 - 1 listed
Short Paper | Special issue | Vol 95, No. 1, 2017, pp. 517 - 524
Published online: 13th July, 2016
PDF (455KB)PDF with Links (484KB)
Published online: 13th July, 2016
DOI: 10.3987/COM-16-S(S)9
■ Preparation and Biological Activity of Novel Twin-Drug Type C2-Symmetrical Cyclic Phenylboronic Acid Derivatives
Makoto Furutachi, Ayumi Ejima, Reika Tsuru, Saho Goto, Toshiaki Gondo, Kenta Ako, Saho Fuchigami, Saya Fujii, Arisa Okumura, Ayumi Tozuka, Kazumi Yokomizo, Jian-Rong Zhou, Hiroshi Inao, Yutaro Ono, Nobuhiro Kashige, Fumio Miake, and Kunihiro Sumoto*
*Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
Abstract
We here report the results of evaluation of antibacterial and anti-herpes simplex virus-1 (HSV-1) activities of a novel twin-drug type C2-symmetrical boronic acid and its pinacol ester derivatives. By using a primitive amide bond formation reaction, various targeted C2-symmetrical cyclic phenylboronic acid derivatives were obtained from the reactions of commercially available amino-substituted phenylboronic acid derivatives and diacid dichlorides. The C2-symmetrical bivalent molecule 3bd containing two cyclic phenylboronic acid pinacol ester moieties and a flexible hexamethylene linker showed both antibacterial activity (S. aureus) and anti-HSV-1 activity. The corresponding boronic acid derivative 3dd showed neither antibacterial nor anti-HSV-1 activity, indicating the importance of two pinacol ester functionalities.
1 data found. 1 - 1 listed
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