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Short Paper | Regular issue | Vol 94, No. 3, 2017, pp. 523 - 530
Published online: 14th March, 2017
DOI: 10.3987/COM-17-13654
Novel O-Benzyl Oxime Ethers of 1-(Thiophen-2-yl)ethan-1-one – Synthesis, Structure and Antimicrobial Activity

Tomasz Kosmalski,* Jolanta Kutkowska, Izabela Dwojak, Renata Studzińska, Adam Sikora, Bożena Modzelewska-Banachiewicz, and Andrzej Gzella

*Department of Organic Chemistry, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland

Abstract

In this study, new O-benzyl oxime ethers of (2-thienyl)ethan-1-one were synthesized and tested for their antimicrobial activity. First, we prepared, in a pure form, (E)-oxime of (2-thienyl)ethan-1-one. Then, we obtained eight final products with good yields and purities. The structure elucidation of the titled compounds was performed by 1H NMR, 13C NMR and mass spectrum. X-Ray analysis was carried out to the compound 7. The compounds were tested to its antimicrobial activities against C. albicans, S. aureus, and E. coli.

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