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Abstract

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Paper | Regular issue | Vol 94, No. 8, 2017, pp. 1542 - 1553
Published online: 19th June, 2017
DOI: 10.3987/COM-17-13746
Synthesis of Isocoumarin Compounds, 8-Hydroxy-6-methoxy-3-Pentyl-1H-Isochromen-1-one and Fusariumin Analog Using Palladium-Catalyzed Carbonylation Trapping with O-Enolate

Masaki Asai, Yasunao Hattori, and Hidefumi Makabe*

*Department of Agriculture, Division of Food Science and Biotechnology, Graduate School of Science and Technology, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan

Abstract

Concise synthesis of 6,8-dialkoxyisocoumarin framework was achieved using Pd-catalyzed carbonylation trapping with O-enolate. This methodology was applied to the synthesis of 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one isolated from Tessmannia densiflora and fusariumin analog.

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