e-Journal

Abstract

1 data found. 1 - 1 listed
Paper | Special issue | Vol 97, No. 2, 2018, pp. 776 - 784
Published online: 26th March, 2018
DOI: 10.3987/COM-18-S(T)50
A Practical Synthesis of Glycinamide Ribonucleotide

Debarpita Ray, Penny J. Beuning,* Mary Jo Ondrechen,* and George A. O'Doherty*

*Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115-5096, U.S.A.

Abstract

A practical nine-step synthesis of an alpha-/beta-anomeric mixture of glycinamide ribonucleotide (GAR) has been developed. The synthesis was accomplished in eight steps from D-ribose and occurred in 9.5% overall yield. The route as devised provided material on the multi-milligram scale

Supporting Info. (3MB)PDF (868KB)PDF with Links (1.1MB)
1 data found. 1 - 1 listed