HETEROCYCLES
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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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December 24, 2019
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e-Journal
Abstract
1 data found. 1 - 1 listed
Short Paper | Regular issue | Vol 96, No. 6, 2018, pp. 1088 - 1100
Published online: 15th May, 2018
PDF (829KB)PDF with Links (901KB)
Published online: 15th May, 2018
DOI: 10.3987/COM-18-13899
■ Preparation of Novel Bivalent Linker Mode Phenylboronic Acid Derivatives and Their Biological Evaluation
Makoto Furutachi, Ayaka Matsumoto, Tetsuya Tamenaga, Aya Sugita, Misato Kuroiwa, Kazumi Yokomizo, Jian-Rong Zhou, Nobuhiro Kashige, Fumio Miake, and Kunihiro Sumoto*
*Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
Abstract
We report a new route to the preparation of C2-symmetrical bivalent phenylboronic acids having alkyl linker groups in the molecule and results of biological evaluation of their biological activity and cytotoxic activity against Vero cells. Among the tested compounds, C2-symmetrical bivalent meta-oriented phenylboronic acid 2f (n=7) showed high cytotoxic activity (CC50=5.43 μM) against Vero cells. The results of an SAR study suggested that the presence of a C7-methylene linker group in the molecule is an important structural factor for expression of potential cytotoxic activities. A sugar recognition property of this C2-symmetrical geometric molecule was suggested by NMR analysis of compound 2f with methyl α-D-glucopyranoside 6.
1 data found. 1 - 1 listed
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