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An International Journal for Reviews and Communications in Heterocyclic ChemistryWeb Edition ISSN: 1881-0942
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Annoucement
Franco Piozzi (1928-2022)
Professor Franco Piozzi,
a member of the Honorary Advisors to the Editorial Board of HETEROCYCLES,
has passed away on February 13, 2022 at the age of 93.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
March 4, 2022
HETEROCYCLES Special Issue Vol. 105 in honor of Professor Somsak Ruchirawat on 80th Birthday

Submission deadline: December 20, 2021
On the occasion of Professor Somsak Ruchirawat's 80th birthday, HETEROCYCLES editorial office is planning to publish special anniversary issue on June 28, 2022 as Vol. 105. Authors are invited to submit their work to this topical issue.
Authors wishing to submit their manuscript should contact editorial office via e-mail by April 26, 2021. Manuscript should reach the editorial office no later than December 20, 2021.
Contact: submit@heterocycles.com
Editorial Office of HETEROCYCLES
February 22, 2021
I think you are in the middle of fighting COVID-19.
Concerned about the difficulty of carrying out your research due to the influence of COVID-19, we decided to extend the deadline for the commemorative issue to celebrate Professor Somsak Ruchirawat's 80 years old.
We would like to extend the deadline by February 20, 2022.
Please submit your manuscript by that time.
I pray for overcoming COVID-19.
Kunio Ogasawara
Editor
May 12, 2021
The publication of all articles is
Free of charge from January 1st 2020.
December 24, 2019
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e-Journal
Abstract
Published online: 20th July, 2018
■ Structure–Activity Relationship Study of Gatastatin Based on the Topliss Tree Approach
Ichiro Hayakawa,* Shuya Shioda, Takumi Chinen, Takeo Usui, and Hideo Kigoshi*
*Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Okayama 700-8530, Japan
Abstract
Various analogues of gatastatin, a γ-tubulin-specific inhibitor, were designed and synthesized by systematically optimizing the aromatic ring at the O7-benzyl group in accordance with an operational Topliss tree, and their biological activities were evaluated. Some derivatives showed stronger cytotoxicity against HeLa cells than gatastatin. Especially, the cytotoxicity of the meta-chloro derivative was about 18-fold stronger than that of gatastatin. However, these derivatives did not exhibit binding ability to the yeast γ-tubulin small complex or inhibitory activity against α,β-tubulin polymerization. These results suggested that γ-tubulin strongly recognized the unsubstituted phenyl ring of the O7-benzyl group in gatastatin.
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