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HETEROCYCLES Special Issue Vol. 105 in honor of Professor Somsak Ruchirawat on 80th Birthday
HETEROCYCLES Special Issue Vol. 105 in honor of Professor Somsak Ruchirawat on 80th Birthday
Submission deadline: December 20, 2021
On the occasion of Professor Somsak Ruchirawat's 80th birthday, HETEROCYCLES editorial office is planning to publish special anniversary issue on June 28, 2022 as Vol. 105. Authors are invited to submit their work to this topical issue.
Authors wishing to submit their manuscript should contact editorial office via e-mail by April 26, 2021. Manuscript should reach the editorial office no later than December 20, 2021.
Contact: submit@heterocycles.com
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February 22, 2021
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e-Journal
Abstract
1 data found. 1 - 1 listed
Paper | Regular issue | Vol 98, No. 3, 2019, pp. 395 - 402
Published online: 27th February, 2019
PDF (364KB)PDF with Links (769KB)
Published online: 27th February, 2019
DOI: 10.3987/COM-19-14037
■ Biological Activity of Sinapic Acid Derivatives Isolated from Raphanus sativus
Takaya Ishida, Aki Hasebe, Xingyun Zhao, and Hideyuki Shigemori*
*Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572 Japan
Abstract
Radish sprout (Raphanus sativus) is a vegetable sprout that contains various sinapic acid derivatives. In this study, three sinapic acid derivatives 1-3 isolated from R. sativus, sinapic acid (4), and compounds 5-7, derived from the methylation of compounds 2-4, respectively, were used to investigate the structure-activity relationship for various bioactivities. Compounds with a number of sinapoyl and phenolic hydroxyl groups were found to have antioxidant and angiotensin converting enzyme (ACE) inhibitory activities. In addition, the sugar domains and the phenolic hydroxyl group in sinapoyl group is related to α-glucosidase inhibitory activity. Therefore, these sinapic acid derivatives are promising candidates to move forward to in vivo studies for the treatment of lifestyle-related diseases such as diabetes and hypertension.
1 data found. 1 - 1 listed
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