Regular Issue

Vol. 24, No. 5, 1986

44 data found. 1 - 30 listed Next Last
Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1193 - 1196
Published online:
DOI: 10.3987/R-1986-05-1193
1,2,5-Thiadiazole-1-oxides. V. Ring Transformations to Pyrazine, 1,2,4-Thiadiazole and Pyrrole

Sandor Karady,* Joseph S. Amato, Robert A. Reamer, and Lonard M. Weinstock

*Division of Merck & Co., Inc., Merck Research Laboratories, P.O.Box 2000, Rahway, NJ 07065, U.S.A.


Rearrangement of 2-alkyl-1,2,5-thiadiazole-3-on-1-oxides to pyrazine, 1,2,4-thiadiazole and pyrrole derivatives is described. Ring opening to a sufinylamine and cyclization by cycloaddition or nucleophilic addition is the postulated mechanism.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1197 - 1201
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DOI: 10.3987/R-1986-05-1197
Asimicin, a New Cytotoxic and Pesticidal Acetogenin from the Pawpaw, Asimina triloba (Annonaceae)

J. Kent Rupprecht, Ching-jer Chang, John M. Cassady, Jerry L. McLaughlin,* Kenneth L. Mikolkajczak, and David Weisleder

*Department of Medicinal Chemistry and Molecular Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 1333 Robert E. Heine Pharmacy Building, West Lafayette IN 47907, U.S.A.


Asimicin, a new trihydroxy-bistetrahydrofuran fatty acid γ-lactone has been isolated, using brine shrimp lethality for activity-directed fractionation, from extracts of the bark and the seeds of the pawpaw tree, Asimina triloba Dunal. (Annonaceae). This compound is extremely cytotoxic and shows promising pesticidal activities.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1203 - 1204
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DOI: 10.3987/R-1986-05-1203
Synthesis of Cryptands under High Pressure. The Role of Solvent and Leaving Group in Double Quaternization Reactions

Marek Pietraszkiewicz, Piotr Salanski, Ryszard Ostaszewski, and Janusz Jurczak*

*Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, P.O.Box 58, PL-01-224 Warszawa 42, Poland


The rate of double quaternization reaction of N,N’-dimethyldiazacoronand (1) with bis(2-iodoethyl) ether (2a) under high pressure strongly depends on solvent polarity. The nature of the leaving group in bis(2-halogenoethyl) ethers (2a-c) or in bis(2-tosyloxyethyl) ether (2d) influences the rate of double quaternization reaction.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1205 - 1208
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DOI: 10.3987/R-1986-05-1205
High-pressure Synthesis of 5,6-Dihydro-2H-pyran System. Eu(fod)3 Mediated (4+2)Cycloaddition of 1-Methoxybuta-1,3-diene to N-Protected α-Amino Aldehydes

Adam Golebiowski, Jan Izdebski, Ulla Jacobsson, and Janusz Jurczak*

*Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, P.O.Box 58, PL-01-224 Warszawa 42, Poland


High-pressure [4+2]cycloaddition of 1-methoxybuta-1,3-diene (1) to N-protected α-amino aldehydes (2) is described. The use of a lanthanide catalyst permits reduction of the required pressure to 10 kbar.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1209 - 1213
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DOI: 10.3987/R-1986-05-1209
Reaction of the 2-Nitroenamine in Acid

Adam Krówczynski and Lech Kozerski*

*Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, P.O.Box 58, PL-01-224 Warszawa 42, Poland


2-Nitroenamines bearing heteroaryl substituents on enamine nitrogen rearrange in acids to amidooxime of the pyruvic acid or give the products of the intramolecular cyclization, di- and triaza-indenes, whereas N-aryl substituted substrates yield quinoxaline oxides. Nitronic acid of the 2-nitroenamine is suggested as a primary reactive species in acid solution. 13C and 15N NMR data are discussed which provide the evidence for this intermediate.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1215 - 1218
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DOI: 10.3987/R-1986-05-1215
Structure Determination of the Ochrosia Alkaloid Ochropposinine: Syntheses of (±)- and (-)-Ochropposinine

Tozo Fujii,* Masashi Ohba, Yakeshi Tachinami, Hisae Miyajima, Michel Koch, and Elisabeth Seguin

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


The tetracyclic alcohols (±)-I and (-)-I have been synthesized from the lactim ethers (±)-III and (+)-III via the intermediates (±)-VII and (+)-VII, (±)-IX and (+)-IX, (±)-X and (+)-X, XI, and (±)-XlI and (-)-XII. The identity of the synthetic (-)-I with natural ochropposinine unequivocally established the structure and absolute stereochemistry of this Ochrosia alkaloid.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1219 - 1222
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DOI: 10.3987/R-1986-05-1219
Nitriles in Heterocyclic Synthesis: Novel Synthesis of Pyridazine Derivatives

Nadia S. Ibrahim,* Fathy M. Abdel Galil, Ramadan M. Abdel-Motaleb, and Mohamed H. Elnagdi

*Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt


The crotononitriles 1a-c coupled with aryldiazonium salts to yield either the acyclic hydrazones or azahydrazones depending on coupling reaction conditions. Both hydrazones and azodrazones could be cyclized to the corresponding pyridazine derivatives. Direct formation of pyridazines on coupling 1b and 1c with aryldiazonium salts was observed. Structures of reaction products are confirmed by spectral and analytical data.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1223 - 1226
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DOI: 10.3987/R-1986-05-1223
A Novel Reductive Amino Cyclization Method and Its Application for the Syntheses of Pyrrolidine and Piperidine Nucleus

Fumio Yamada, Toshifumi Hasegawa, Masayuki Wakita, Mitsuru Sugiyama, and Masanori Somei*

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


A novel synthetic method for pyrrolidine and piperidine derivatives is developed. Its versatility is proved by the syntheses of 6a,9a-cis-6,6a,7,8,9,9a-hexahydro-2H-isoindolo[4,5,6-cd]indole and cactus alkaloid, (±)-lophocerine.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1227 - 1230
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DOI: 10.3987/R-1986-05-1227
(+)-Roemearine, a C-4 Hydroxylated Tetrahydrobenzylisoquinoline Alkaloid

Tekant Gözler,* Belkis Gözler, Nevin Tanker, Alan J. Freyer, Hélène Guinaudeau, and Maurice Shamma

*Department of Chemistry, The Pennsylvania State University, York Campus, P1031 Edgecomb Avenue, York, Pennsylvania 17403, U.S.A.


Roemeria carica A. Baytop (Papaveraceae) of Turkish origin has supplied (+)-roemecarine (1), which is the first C-4 hydroxylated tetrahydrobenzylisoquinoline alkaloid. Species 1 is accompanied in the plant extract by its N-oxide, (+)-roemecarine 2-α-N-oxide (4).

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1231 - 1232
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DOI: 10.3987/R-1986-05-1231
Reduction of N-Alkoxycarbonyllactams with NaBH4/EtOh-H+: A Facile Synthesis of α-Ethoxyurethanes

Tatsuo Nagasaka,* Hirohisa Tamano, and Fumiko Hamaguchi

*School of Pharmacy, Tokyo University of Pharmacy and Life Science,1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


Reduction of N-alkoxycarbonyllactams with NaBH4/H+ in ethanol (Speckamp’s condition) afforded α-ethoxyurethanes (Shono’s compounds) in good yields.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1233 - 1236
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DOI: 10.3987/R-1986-05-1233
Preparation of Naphthalene Derivatives by Reaction of Benzynes with Thiophene-1,1-dioxides

Juzo Nakayama,* Masami Kuroda, and Masamatsu Hoshino

*Department of Chemistry, Faculty of Science, Saitama University, Saitama, Saitama 338-8570, Japan


The reaction of benzynes with thiophene 1,1-dioxides affords the Diels-Alder cycloadducts which spontaneously lose sulfur dioxide to give the corresponding naphthalene derivatives in moderate yields. Further reaction of benzyne with naphthalenes yielding dibenzobarrelenes is observed in a few cases.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1237 - 1242
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DOI: 10.3987/R-1986-05-1237
1,3-Anionic Cycloaddition of 1,3-Diphenyl-2-azaallyl Lithium to Thioketenes and Thioketene S-Oxides

Ernst Schaumann,* Helmut Behr, and Gunadi Adiwidjaja

*Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, D-20416 Hamburg, Germany


Cycloaddition of 1,3-diphenyl-2-azaallyl lithium (4) to the thioketenes 5a,b leads to thiazolidines 7a,b. Evidence for an open-chain anionic intermediate 8 is obtained by trapping with methyl iodide and through the stereochemistry of 7a as revealed in an X-ray crystallographic study. With thioketene S-oxides 10a,b, 4 yields thiazoles 15 via a ‘second-generation’ Pummerer reaction.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1243 - 1246
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DOI: 10.3987/R-1986-05-1243
Studies on as-Triazine Derivatives. VII. Resemblance between as-Triazines and Quinazolines in Nucleophilic Addition-elimination Reactions

Shoetsu Konno, Setsuya Ohba, Mataichi Sagi, and Hiroshi Yamanaka*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


Alike 4-chloroquinazoline, 5-chloro-1,2,4-triazines (as-triazines) reacted with aromatic aldehydes in the presence of 1,3-dimethylbenzimidazolium iodide under basic conditions to give 5-aroyl-as-triazines. The Grignard reaction of 5-cyano-as-triazine with arylmagnesium bromides failed to give any significant product. Some analogy of as-triazines with quinazolines, in their chemical properties, was additionally investigated.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1247 - 1250
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DOI: 10.3987/R-1986-05-1247
Metallo-ketene-S,N-acetals. New Synthesis of Azacycloalka[3,2-c]pyridin-2-ones

Hiroki Takahata, Toshiaki Suzuki, and Takao Yamazaki*

*Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan


S-Lithio-ketene-S,N-actals (3 and 4), generated from N-methylthiolactams (1 and 2) with n-buthyllithium (n-BuLi), react with aryl isocyanates (5) to give 3-(N-arylcarbamoyl)thiolactams (6 and 7), which are transformed into azacycloalka[3,2-c]pyridine-2-ones (12 and 13), respectively, using sulfide extrusion of thioiminium salts (8 and 9) with malononitrile followed by cyclization.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1251 - 1255
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DOI: 10.3987/R-1986-05-1251
Structure of Mulberrofuran M, a Novel 2-Arylbenzofuran Derivative from the Cultivated Mulberry Tree (Morus alba L).

Yoshio Hano, Kazuhiro Hirakura, Takehisa Someya, and Taro Nomura*

*Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan


A novel 2-arylbenzofuran derivative named mulberrofuran M (1) was isolated from an acetone extract of the reddish violet powder obtained from the surface of the root bark of cultivated mulberry tree (Ichinose, a cultivated variety of Morus alba L.). The structure was shown to be 1 on the basis of spectral evidence.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1257 - 1260
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DOI: 10.3987/R-1986-05-1257
Structure and Syntheses of SEN-125 and Oxotomaymycin

Miwako Mori,* Yasuhiro Uozumi, and Yoshio Ban

*Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan


The structure of SEN-215 was determined as (11aS)(E)-2-ethylidene-2,3,5,10,11,11a-hexahydro-8-hydroxy-7-methoxy-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine by conversion of (E)- and (Z)-pretomaymycin into (E)- and (Z)-SEN-215.

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Communication | Regular issue | Vol 24, No. 5, 1986, pp. 1261 - 1264
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DOI: 10.3987/R-1986-05-1261
A Novel Skeletal Rearrangement of an Indolizidine Alkaloid, Swainsonine via an Aziridinium Intermediate

Hiroyuki Setoi, Hidekazu Takeno, and Masashi Hashimoto*

*Fujisawa Pharmaceutical Co. Ltd., 5-2-3 Tokodai, Tsukuba, Ibaragi 300-2635, Japan


Nucleophilic displacement reactions of mesylate 3, derived from swainsonine (1), gave the rearranged products 5 along with the swainsonine-type products 6 via an aziridinium intermediate 4.

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Report | Regular issue | Vol 24, No. 5, 1986, pp. 1265 - 1269
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DOI: 10.3987/R-1986-05-1265
Lincomycin Analogues. II. Chain-extension of Methyl-6-aldehydo-3,4-O-isopropylidene-1-thio-β-D-galcto-1,5-pyranoside

Jean M. J. Tronchet and Mohamed A. M. Massoud*

*Pharmaceutical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt


Synthesis of methyl 2,3,4,6-tetra-O-acetyl-1-thio-α-D-galactopyranoside and its β-anomer (3 and 4) from the 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl brormide via the isothiauronium salt in HMPT involved a considerable increase in the proportion of the α-anomer. Deacetylation of (3 and 4) with sodium methoxide yielded 5 and 6 respectively. Conversion of (6) into the corresponding 3,4-isopropylidene derivative (7) followed by oxidation with Collin reagent gave the aldehydo-sugar (8) which when reacted with a stabilised phosphorane led in excellent yield to the Z-unsaturated bromo-sugar (9).

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Report | Regular issue | Vol 24, No. 5, 1986, pp. 1271 - 1274
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DOI: 10.3987/R-1986-05-1271
Sensitized Photooxidation of 2,5-Furanyldimethyl Dibenzoate

Yueh-Hsiung Kuo* and Chir-Jeng Shieh

*Department of Chemistry, National Taiwan University, Roosevelt Road Section 4, Taipei 106, Taiwan, R.O.C.


Sensitized photooxidation of 2,5-furanyldimethyl dibenzoate was carried out in acetonitrile and methanol respectively. Two products, 3 and 6, were obtained via O,O-diradical intermediate 15 which was discovered from ozonide for the first time.

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Report | Regular issue | Vol 24, No. 5, 1986, pp. 1275 - 1277
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DOI: 10.3987/R-1986-05-1275
The Structure of Heterophylloidine and Panicutine

S. William Pelletier,* Balawant S. Joshi, Haridutt K. Desai, Al Panu, and Alfred Katz

*Department of Chemistry, Institute for Natural Products Research, The University of Georgia, Chemistry Building, Athens, Georgia 30602-2556, U.S.A.


Heterophylloidine (Aconitum heterophylloides Stapf) and panicutine (A. paniculatum Lam.) have been shown to be identical. CD measurements on derivatives of heterophylloidine and hetisine indicate that the keto groups in panicutine must be located at C(6), C(13) and not at C(6), C(11) as previously reported. The structure of panicutine is therefore 1, as proposed earlier for heterophylloidine.

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Report | Regular issue | Vol 24, No. 5, 1986, pp. 1279 - 1284
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DOI: 10.3987/R-1986-05-1279
Nitrogen Assisted Acetal Ring Clevage. Part II. Preparation of Synthons for Eburnamine-vincamine Alkaloids

Mauri Lounasmaa* and Arto Tolvanen

*Laboratory of Organic Chemistry, Helsinki University of Technology, P.O. Box 6100,FIN-02015 HUT, Espoo, Finland


The cleavage of cyclic 3-substituted tetrahydropyridine acetals under the modified Polonovski reaction conditions is described. The method was applied to the preparation of a 1-formylindolo[2,3-a]quinolizidine derivative.

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Report | Regular issue | Vol 24, No. 5, 1986, pp. 1285 - 1286
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DOI: 10.3987/R-1986-05-1285
Synthesis of Novel Methyl (2-Oxo-3-morpholinylodene)acetates

George B. Mullen, Vassil St. Georgiev,* and Chiristopher G. Acker

*Department of Organic Chemistry, Pharmaceutical Division, Pennwalt Corporation, Rochester, New York 14623, U.S.A.


The synthesis of a series of novel (2-oxo-3-morpholinylidene)acetic acid methyl esters is described.

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Report | Regular issue | Vol 24, No. 5, 1986, pp. 1287 - 1289
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DOI: 10.3987/R-1986-05-1287
Synthesis of (2S,5S)-2,5-Bis(phenylmethyl)piperazine by the Reduction with Sodium Borohydride Using Titanium Tetrachloride

Kenso Soai,* Hiroshi Hayashi, and Hitoshi Hasegawa

*Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka 1-3, Shinjuku-ku, Tokyo 162-8601, Japan


Optically active piperazine 1 is synthesized in relatively high yield by the reduction of cyclo-L-Phe-L-Phe with sodium borohydride-titanium tetrachloride.

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Report | Regular issue | Vol 24, No. 5, 1986, pp. 1291 - 1294
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DOI: 10.3987/R-1986-05-1291
Termolysis of Sodium Salt of Furfural Tosylhydrazone in the Presence of Silver Chromate: Formation of 2-Furyl(p-toluenesulfonyl)methane via 1,3-NC Migration of Tosyl Group

Katsuhiro Saito* and Hiraku Ishihara

*Faculty of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan


The thermal decomposition of sodium salt of furfural tosylhydrazone in diglyme in the presence of silver chromate afforded trans-1,2-di(2-furyl)ethylene and 2-furyl(p-toluenesulfonyl)methane. The former product is formed via (2-furyl)methylene, while the latter product is considered to be derived via 1,3 N→C migration of tosyl group in furfural tosylhydrazyl radical, which is generated by one electron oxidation of furfural tosylhydrazone by silver chromate.

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Paper | Regular issue | Vol 24, No. 5, 1986, pp. 1295 - 1299
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DOI: 10.3987/R-1986-05-1295
Horridine, a New Isoeuonyminol Skeleton Alkaloid

Antonio G. González,* Esteban A. Ferro, and Angel G. Ravelo

*Instituto Universitario de Química Orgánica, Universidad de La Laguna, Tenerife, Canary Islands, Spain


The structure of a new alkaloid, horridine, isolated from the ethanol extract of the root bark of Maytenus horrida Reiss (Celastraceae) was established from spectral and degradation data.

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Paper | Regular issue | Vol 24, No. 5, 1986, pp. 1301 - 1309
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DOI: 10.3987/R-1986-05-1301
A Carbon-13 and Proton Nuclear Magnetic Resonance Study of Hydroxy- and Mercapto-nitropyridines and Their N-, O-, and S-Methyl Derivatives and Analogous Compounds in Dimethyl Sulfoxide

Gordon B. Barlin* and M. David Fenn

*Department of Pharmacology, John Curtin School of Medical Research, Australian National University, GPOBox 334, Canberra, ACT 2601, Australia


Carbon-13 and proton n.m.r. spectra of hydroxy- and mercapto-nitropyridines and their N-, O- and S-methyl derivatives and analogous compounds have been measured in (D6)dimethyl sulfoxide. Carbon-13 n.m.r. spectroscopy, in contrast to 1H n.m.r. spectroscopy, has bean shown to provide a clear distinction between O-methyl and nuclear N-methyl groups. Methoxy groups were found to occur in the range δ 52.80 to 57.18, nuclear N-methyl groups at 33.59-43.56, and methylthio groups at 12.00-14.65 for the compounds examined in (D6)dimethyl sulfoxide. 3-Nitropyridine-4-thiol† unlike its oxygen analogue, 3-nitropyridin-4-ol† appears to exist in the thiol form.

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Paper | Regular issue | Vol 24, No. 5, 1986, pp. 1311 - 1318
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DOI: 10.3987/R-1986-05-1311
A New Mechanism (SEi) for Electrophilic Substitution in Indoles. Chlorination of Indoles with Sodium Hypochlorite by Competitive SE2 and SEi Mechanisms

Michael De Rosa,* Angela Cuenca, and Maria Raquel Fernandez

*Departamento de Quimica, Universidad Simon Bolivar, Apartado 80659, Caracas 1080-A, Venezuela


The chlorination of 5-substituted indoles (OCH 3, CH3, Br, CN, NO2) with NaOCl was studied. Mixtures of N-chloro- and N-chloro-3-chloro-indoles were formed. Indoles reacted with OCl- in a SEi process to give N-chloroindoles. This reaction was favored by substituents which increased the acidity of the indolic N-H. Indoles or their conjugate bases also reacted with HOCl in a SE2 reaction to give 3-chloroindoles which were then converted to their N-chloro derivatives with excess NaOCl.

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Paper | Regular issue | Vol 24, No. 5, 1986, pp. 1319 - 1324
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DOI: 10.3987/R-1986-05-1319
Isolation of a New Tetranortrietrpenoid from Azadirachta indica A, Juss (Meliaceae)

Salimuzzaman Siddiqui,* Shaheen Faizi, Tariq Mahmood, and Bina Shaheen Siddiqui

*H. E. J. Postgraduate Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan


A new γ-hydroxybutenolide tetranortriterpenoid named as isonimbocinolide has been isolated from the acidic fraction of the fresh, undried leaves of Azadirachta indica A. Juss (neem) and its structure established through chemical and spectral studies. This fraction showed insect growth regulating properties against mosquitoes (Aedes aegypti).

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Paper | Regular issue | Vol 24, No. 5, 1986, pp. 1325 - 1329
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DOI: 10.3987/R-1986-05-1325
One-flask Synthesis of 4-[Bis(methylthio)]methylene-2-phenyl-5-oxo-4,5-dihydro-1,3-oxazole and Its Aminolyses

Ram Ashare, Jalpana Roy, and Arya K. Mukerjee*

*Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi - 221005, India


Cyclisation of hippuric acid with ethyl chloroformate and triethylamine in benzene and subsequent triethylaminemediated condensation with carbon disulphide and S-methylation afford the title compound which undergoes 1,5-bond cleavage on heating with molar proportion of a primary amine in the presence of glacial acetic acid, the ketenethioacetal moiety remaining intact. On increasing the proportion of the amine and heating the mixture for a longer period, the corresponding N,N’-disubstituted benzoylaminomalondiamides are obtained.

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Paper | Regular issue | Vol 24, No. 5, 1986, pp. 1331 - 1346
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DOI: 10.3987/R-1986-05-1331
Synthesis of Optically Active 3-Mercaptopyrrolidine Derivatives. Synthetic Intermediates of Carbapenem RS-533 and Its Isomer

Tomoyuki Shibata, Kimio Iino, and Yukio Sugimura*

*Chemical Research Laboratories and Analytical & Metabolic Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan


The optically active 3-mercaptopyrrolidine derivatives(3a, 3b, 4a and 4b), which are synthetic intermediates of the carbapenem RS-533 (2a) and its isomer (2b), were synthesized by convenient and practical methods.

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44 data found. 1 - 30 listed Next Last