Natural Products with Heterocyclic Ring System

Synthesis

New Heterocyclic Natural Products

Updated: 7 November, 2019

This journal will list the new natural products with a heterocyclic ring system, collected from current chemical literature, whose synthesis has been established.

65 data found. 1 - 30 listed Next Last
Polyketides

Jaspine B

C18H37NO2 = 299
Synlett 2019, 30, 185
H. Alnazer, T. Castellan, Y. Salma, Y. Génisson, S. Ballereau
DOI: 10.1055/s-0037-1610344
CrossRef
chiral
racemic
Notes:
Polyketides

Cryptoconcatone H

C19H22O4 = 314
Synlett 2019, 30, 178
D. Csókás, R. W. Bates
DOI: 10.1055/s-0037-1609657
CrossRef
chiral
racemic
Notes:
Polyketides

Laurallene

C15H20O2Br2 = 392
Org. Lett. 2019, 21, 559
F. Yoshimura, T. Okada, K. Tanino
DOI: 10.1021/acs.orglett.8b03889
CrossRef
chiral
racemic
Notes:
Polyketides

Sinulariadiolide

C20H26O8 = 394
J. Am. Chem. Soc. 2019, 141, 805
Z. Meng, A. Fürstner
DOI: 10.1021/jacs.8b12185
CrossRef
chiral
racemic
Notes:
Polyketides

Rhizoxin D

C35H47NO7 = 593
Angew. Chem. Int. Ed. 2019, 58, 248
P. Karier, F. Ungeheuer, A. Ahlers, F. Anderl, C. Wille, A. Fürstner
DOI: 10.1002/anie.201981213
CrossRef
chiral
racemic
Notes: formal synthesis
Polyketides

Archazolid F

C41H60N2O7S = 724
Org. Lett. 2019, 21, 271
S. Scheeff, D. Menche
DOI: 10.1021/acs.orglett.8b03715
CrossRef
chiral
racemic
Notes:
Aromatics

Diaporthenone A

C12H10O4 = 218
Tetrahedron Lett. 2019, 60, 52
M. A. Tan, P. P. Züger, S. Roggo
DOI: 10.1016/j.tetlet.2018.11.055
CrossRef
chiral
racemic
Notes: chiral separation py HPLC
Aromatics

No Name

C17H16O4 = 284
Org. Lett. 2019, 21, 575
M.-M. Li, Y. Wu, B. Liu
DOI: 10.1021/acs.orglett.8b03965
CrossRef
chiral
racemic
Notes:
Aromatics

Dipetalolactone

C19H18O4 = 310
J. Heterocycl. Chem. 2019, 56, 99
E.-E. N. Vlachou, C. Gabriel, K. E. Litinas
DOI: 10.1002/jhet.3376
CrossRef
chiral
racemic
Notes:
Aromatics

No Name

C17H16O6 = 316
Org. Lett. 2019, 21, 575
M.-M. Li, Y. Wu, B. Liu
DOI: 10.1021/acs.orglett.8b03965
CrossRef
chiral
racemic
Notes:
Aromatics

Diproindonesin G

C21H12O6 = 360
Tetrahedron Lett. 2019, 60, 300
D. K. Singh, I. Kim
DOI: 10.1016/j.tetlet.2018.12.036
CrossRef
chiral
racemic
Notes:
Terpenes

Darwinolide

C22H32O5 = 376
Angew. Chem. Int. Ed. 2019, 58, 1120
T. Siemon, S. Steinhauer, M. Christmann
DOI: 10.1002/anie.201981213
CrossRef
chiral
racemic
Notes:
Steroids

Pleurocin A

C28H44O4 = 444
J. Am. Chem. Soc. 2019, 141, 1222
R. C. Heinze, P. Heretsch
DOI: 10.1021/jacs.8b13356
CrossRef
chiral
racemic
Notes:
Steroids

Pleurocin B

C28H46O4 = 446
J. Am. Chem. Soc. 2019, 141, 1222
R. C. Heinze, P. Heretsch
DOI: 10.1021/jacs.8b13356
CrossRef
chiral
racemic
Notes:
Alkaloids

Muscarine

C9H20NO2 = 174
Tetrahedron Lett. 2019, 60, 423
V. Rodríguez-Tzompanzi, L. Quintero, D. M. Tepox-Luna, S. Cruz-Gregorio, F. Sartillo-Piscil
DOI: 10.1016/j.tetlet.2018.12.058
CrossRef
chiral
racemic
Notes:
Alkaloids

Epiquinamide

C11H20N2O = 196
Tetrahedron 2019, 75, 533
K. Lumyong, B. Kongkathip, N. Chuanopparat, N. Kongkathip
DOI: 10.1016/j.tet.2018.12.045
CrossRef
chiral
racemic
Notes:
Alkaloids

Lycopodine

C16H25NO = 247
Tetrahedron Lett. 2019, 60, 187
K. Wada, N. Kogure, M. Kitajima, H.Takayama
DOI: 10.1016/j.tetlet.2018.12.007
CrossRef
chiral
racemic
Notes:
Alkaloids

Microcosamine A

C16H27NO = 249
J. Org. Chem. 2019, 84, 94
L. Macha, H.-J. Ha
DOI: 10.1021/acs.joc.8b02342
CrossRef
chiral
racemic
Notes:
Alkaloids

Goniothaline B

C14H11NO4 = 257
Synthesis 2019, 51, 552
S. Ahn, J. A Yoon, Y. T. Han
DOI: 10.1055/s-0037-1610909
CrossRef
chiral
racemic
Notes:
Alkaloids

Flabelliformine

C16H25NO2 = 263
Tetrahedron Lett. 2019, 60, 187
K. Wada, N. Kogure, M. Kitajima, H.Takayama
DOI: 10.1016/j.tetlet.2018.12.007
CrossRef
chiral
racemic
Notes:
Alkaloids

Microgrewiapine A

C17H29NO = 263
J. Org. Chem. 2019, 84, 94
L. Macha, H.-J. Ha
DOI: 10.1021/acs.joc.8b02342
CrossRef
chiral
racemic
Notes: Revised structure
Alkaloids

Goniothaline A

C15H13NO4 = 271
Synthesis 2019, 51, 552
S. Ahn, J. A Yoon, Y. T. Han
DOI: 10.1055/s-0037-1610909
CrossRef
chiral
racemic
Notes:
Alkaloids

Aspidospermidine, 1,2-Dehydro-

C19H24N2 = 280
Angew. Chem. Int. Ed. 2019, 58, 1174
H.-Y. Bin, K. Wang, D. Yang, X.-H. Yang, J.-H. Xie, Q.-L. Zhou
DOI: 10.1002/anie.201981213
CrossRef
chiral
racemic
Notes: formal synthesis
Alkaloids

Aspidospermidine

C19H26N2 = 282
Angew. Chem. Int. Ed. 2019, 58, 1174
H.-Y. Bin, K. Wang, D. Yang, X.-H. Yang, J.-H. Xie, Q.-L. Zhou
DOI: 10.1002/anie.201981213
CrossRef
chiral
racemic
Notes: formal synthesis
Alkaloids

Suaveoline, Nor-

C19H19N3 = 289
Angew. Chem. Int. Ed. 2019, 58, 1148
Z. Zhao, H. Wei, K. Xiao, B. Cheng, H. Zhai, Y. Li
DOI: 10.1002/anie.201981213
CrossRef
chiral
racemic
Notes:
Alkaloids

Lycoricidine

C14H13NO6 = 291
J. Am. Chem. Soc. 2019, 141, 657
T. W. Bingham, L. W. Hernandez, D. G. Olson, R. L. Svec, P. J. Hergenrother, D. Sarlah
DOI: 10.1021/jacs.8b12123
CrossRef
chiral
racemic
Notes:
Alkaloids

Goniomitine

C19H26N2O = 298
Angew. Chem. Int. Ed. 2019, 58, 1174
H.-Y. Bin, K. Wang, D. Yang, X.-H. Yang, J.-H. Xie, Q.-L. Zhou
DOI: 10.1002/anie.201981213
CrossRef
chiral
racemic
Notes:
Alkaloids

Ibogamine, 19-Hydroxy-

C19H26N2O = 298
Org. Biomol. Chem. 2019, 17, 66
Z. T. I. Alkayar, I. Coldman
DOI:  10.1039/C8OB02839G
CrossRef
chiral
racemic
Notes: formal synthesis
Alkaloids

Macrophylline

C21H22N2 = 302
Angew. Chem. Int. Ed. 2019, 58, 1148
Z. Zhao, H. Wei, K. Xiao, B. Cheng, H. Zhai, Y. Li
DOI: 10.1002/anie.201981213
CrossRef
chiral
racemic
Notes:
Alkaloids

Suaveoline

C20H21N3 = 303
Angew. Chem. Int. Ed. 2019, 58, 1148
Z. Zhao, H. Wei, K. Xiao, B. Cheng, H. Zhai, Y. Li
DOI: 10.1002/anie.201981213
CrossRef
chiral
racemic
Notes:
65 data found. 1 - 30 listed Next Last