Natural Products with Heterocyclic Ring System

Synthesis

New Heterocyclic Natural Products

Updated: 31 October, 2018

This journal will list the new natural products with a heterocyclic ring system, collected from current chemical literature, whose synthesis has been established.

94 data found. 1 - 30 listed Next Last
Polyketides

Aspinolide A

C10H16O3 = 184
J. Org. Chem. 2018, 83, 980
A. M. Sherwood, S. E. Williamson, S. N. Johnson, A. Yilmaz, V. W. Day, T. E. Prisinzano
DOI: 10.1021/acs.joc.7b02324
CrossRef
chiral
racemic
Notes:
Polyketides

Stagonolide F

C10H18O3 = 184
J. Org. Chem. 2018, 83, 980
A. M. Sherwood, S. E. Williamson, S. N. Johnson, A. Yilmaz, V. W. Day, T. E. Prisinzano
DOI: 10.1021/acs.joc.7b02324
CrossRef
chiral
racemic
Notes: proposed structure
Polyketides

Brasilenyne

C15H19OCl = 250.5
Chem. Commun. 2018, 54, 467
C. Lim, J. Ahn, J. Sim, H. Yun, J. Hur, H. An, J. Jang, S. Lee, Y.-G. Suh
DOI: 10.1039/C7CC08329G
CrossRef
chiral
racemic
Notes:
Polyketides

Cryptocaryalactone, 6R, 2’S

C17H18O4 = 286
Tetrahedron Lett. 2018, 59, 160
Y. N. Reddy, T. N. Kumari, P. Thota, P. Jyothi, A. K. Gupta
DOI: 10.1016/j.tetlet.2017.12.014
CrossRef
chiral
racemic
Notes:
Polyketides

Cryptocaryalactone, 6S, 2’R

C17H18O4 = 286
Tetrahedron Lett. 2018, 59, 160
Y. N. Reddy, T. N. Kumari, P. Thota, P. Jyothi, A. K. Gupta
DOI: 10.1016/j.tetlet.2017.12.014
CrossRef
chiral
racemic
Notes:
Polyketides

Synargentolide B

C16H22O8 = 342
Tetrahedron Lett. 2018, 59, 291
Y. Gao, J. Liu, J. Qiao, Y. Liu, P. He, Y. Du
DOI: 10.1016/j.tetlet.2017.12.039
CrossRef
chiral
racemic
Notes: synthesis of enantiomer
Polyketides

Disciformycin A

C27H40O10 = 524
Chem. Eur. J. 2018, 24, 109
Y. Kwon, S. Schulthoff, Q. M. Dao, C. Wirtz, A. Fürstner
DOI: 10.1002/chem.201705550
CrossRef
chiral
racemic
Notes:
Polyketides

Disciformycin B

C27H40O10 = 524
Chem. Eur. J. 2018, 24, 109
Y. Kwon, S. Schulthoff, Q. M. Dao, C. Wirtz, A. Fürstner
DOI: 10.1002/chem.201705550
CrossRef
chiral
racemic
Notes:
Polyketides

Callyspongiolide

C33H42NO6Br = 628
J. Am. Chem. Soc. 2018, 140, 1280
F. Manoni, C. Rumo, L. Li, P. G. Harran
DOI: 10.1021/jacs.7b13591
CrossRef
chiral
racemic
Notes:
Polyketides

Azaspiracid-3

C46H69NO12 = 827
Angew. Chem. Int. Ed. 2018, 57, 810
N. T. Kenton, D. Adu-Ampratwum, A. A. Okumu, P. McCarron, J. Kilcoyne, F. Rise, A. L. Wilkins, C. O. Miles, C. J. Forsyth
DOI: 10.1002/anie.201711008
CrossRef
chiral
racemic
Notes:
Polyketides

Bryostatin 8

C45H68O17 = 880
Angew. Chem. Int. Ed. 2018, 57, 942
Y. Zhang, Q. Guo, X. Sun, J. Lu, Y. Cao, Q. Pu, Z. Chu, L. Gao, Z. Song
DOI: 10.1002/anie.201711452
CrossRef
chiral
racemic
Notes:
Aromatics

Seselin

C14H12O3 = 228
Eur. J. Org. Chem. 2018, , 223
B. Schmidt, C. Schultze
DOI: 10.1002/ejoc.201701684
CrossRef
chiral
racemic
Notes:
Aromatics

Descurainolide A

C13H16O5 = 252
Org. Biomol. Chem. 2018, 16, 266
O. S. Ojo, B. Nardone, S. F. Musolino, A. R. Neal, L. Wilson, T. Lebl, A. M. Z. Slawin, D. B. Cordes, J. E. Taylor, J. H. Naismith, A. D. Smith, N. J. Westwood
DOI: 10.1039/C7OB02697H
CrossRef
chiral
racemic
Notes: synthesis of both enantiomers
Aromatics

Braylin

C15H14O4 = 258
Eur. J. Org. Chem. 2018, , 223
B. Schmidt, C. Schultze
DOI: 10.1002/ejoc.201701684
CrossRef
chiral
racemic
Notes:
Aromatics

Cannabinol

C21H26O2 = 310
Org. Lett. 2018, 20, 252
S. Zhang, L. Li, H. Wang, Q. Li, W. Liu, K. Xu, C. Zeng
DOI: 10.1021/acs.orglett.7b03617
CrossRef
chiral
racemic
Notes: formal synthesis
Aromatics

Dipetalolactone

C19H18O4 = 310
Eur. J. Org. Chem. 2018, , 223
B. Schmidt, C. Schultze
DOI: 10.1002/ejoc.201701684
CrossRef
chiral
racemic
Notes:
Aromatics

Cannabinol, Δ9-trans-Tetrahydro-

C21H30O2 = 314
Org. Lett. 2018, 20, 381
Z. P. Shultz, G. A. Lawrence, J. M. Jacobson, E. J. Cruz, J. W. Leahy
DOI: 10.1021/acs.orglett.7b03668
CrossRef
chiral
racemic
Notes:
Aromatics

No Name

C31H28O12 = 592
Org. Biomol. Chem. 2018, 16, 585
D.-M. Huang, H.-J. Li, J.-H. Wang, Y.-C. Wu
DOI: 10.1039/C7OB02837G
CrossRef
chiral
racemic
Notes:
Aromatics

No Name

C31H28O12 = 592
Org. Biomol. Chem. 2018, 16, 585
D.-M. Huang, H.-J. Li, J.-H. Wang, Y.-C. Wu
DOI: 10.1039/C7OB02837G
CrossRef
chiral
racemic
Notes:
Aromatics

Talienbisflavan A

C45H36O20 = 896
Org. Biomol. Chem. 2018, 16, 585
D.-M. Huang, H.-J. Li, J.-H. Wang, Y.-C. Wu
DOI: 10.1039/C7OB02837G
CrossRef
chiral
racemic
Notes:
Terpenes

Conosilane A

C15H16O5 = 276
Chem. Commun. 2018, 54, 912
Z. Yuan, X. Hu, H. Zhang, L. Liu, P. Chen, M. He, X. Xie, X. Wang, X. She
DOI: 10.1039/C7CC09367E
CrossRef
chiral
racemic
Notes:
Terpenes

Carlactonic Acid

C19H24O5 = 332
J. Org. Chem. 2018, 83, 125
M. C. Dieckmann, P.-Y. Dakas, A. D. Mesmaeker
DOI: 10.1021/acs.joc.7b02465
CrossRef
chiral
racemic
Notes:
Terpenes

Maoecrystal P

C20H22O5 = 342
Angew. Chem. Int. Ed. 2018, 57, 760
F. Su, Y. Lu, L. Kong, J. Liu, T. Luo
DOI: 10.1002/anie.201711084
CrossRef
chiral
racemic
Notes:
Terpenes

Basiliolide A1

C20H24O5 = 344
Eur. J. Org. Chem. 2018, , 196
W. Ma, X. Liang, W. Ye, Y. Wang, L. Min, S. He, C.‐S. Lee
DOI: 10.1002/ejoc.201701211
CrossRef
chiral
racemic
Notes:
Terpenes

Basiliolide A2

C20H24O5 = 344
Eur. J. Org. Chem. 2018, , 196
W. Ma, X. Liang, W. Ye, Y. Wang, L. Min, S. He, C.‐S. Lee
DOI: 10.1002/ejoc.201701211
CrossRef
chiral
racemic
Notes:
Terpenes

Methyl Carlactonate

C20H20O5 = 346
J. Org. Chem. 2018, 83, 125
M. C. Dieckmann, P.-Y. Dakas, A. D. Mesmaeker
DOI: 10.1021/acs.joc.7b02465
CrossRef
chiral
racemic
Notes:
Terpenes

Rosmanol, Iso-

C20H26O5 = 346
J. Org. Chem. 2018, 83, 437
Z. Li, X. Zhang, Z. Yang, Y. Zhang, Z. Xie
DOI: 10.1021/acs.joc.7b02369
CrossRef
chiral
racemic
Notes:
Terpenes

Sarcophytin

C21H30O5 = 362
Angew. Chem. Int. Ed. 2018, 57, 823
L. J. Nannini, S. J. Nemat, E. M. Carreira
DOI: 10.1002/anie.201711372
CrossRef
chiral
racemic
Notes:
Terpenes

Basiliolide C

C22H26O7 = 388
Eur. J. Org. Chem. 2018, , 196
W. Ma, X. Liang, W. Ye, Y. Wang, L. Min, S. He, C.‐S. Lee
DOI: 10.1002/ejoc.201701211
CrossRef
chiral
racemic
Notes:
Terpenes

Przewalskin A

C23H30O6 = 402
J. Org. Chem. 2018, 83, 437
Z. Li, X. Zhang, Z. Yang, Y. Zhang, Z. Xie
DOI: 10.1021/acs.joc.7b02369
CrossRef
chiral
racemic
Notes:
94 data found. 1 - 30 listed Next Last