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Communication | Regular issue | Vol 53, No. 5, 2000, pp.1017-1019
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8870
The First Total Synthesis of Bufobutanoic Acid by Two Routes Based on Nucleophilic Substitution Reaction on Indole Nucleus

Takashi Kurauchi, Yoshiyuki Nagahama, Masakazu Hasegawa, Koji Yamada, and Masanori Somei*

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

Regioselective nucleophilic substitution reaction of 1-hydroxytrypta- mines led to establish two novel routes for the first synthesis of bufobutanoic acid. An effective synthesis of 5-benzyloxytryptamine from tryptamine is also reported.