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Paper | Regular issue | Vol 53, No. 8, 2000, pp.1725-1736
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8930
Syntheses of Melatonin and Its Derivatives

Masanori Somei,* Yoshikazu Fukui, Masakazu Hasegawa, Naoki Oshikiri, and Toshikatsu Hayashi

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

Two simple synthetic methods for melatonin are newly developed from tryptamine through intermediates, which are promising lead compounds for drug developing research. Novel chemical reactivities of melatonin in its bromi- nation, lithiation, and acylation are also reported.