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Note | Regular issue | Vol 53, No. 8, 2000, pp.1811-1819
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8963
Total Synthesis of (+)-Galanolactone

Masako Nozawa, Eriko Ono, and Hiroyuki Akita*

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

Regioselective monobenzylation of the chemoenzymatically prepared chiral decalin-type diol ((8aS)-6) via the benzylidene acetal ((8aS)-11) afforded the primary alcohol ((8aS)-7), from which total synthesis of (+)-galanolactone (1) was achieved and formal syntheses of (+)-(E)-8β(17),12-labddiene-15,16-dial ((+)-3) and (+)-coronarin E (4) were carried out.