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Communication | Regular issue | Vol 53, No. 10, 2000, pp.2123-2125
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8993
Reaction of 3-Ethoxycarbonylindolizine-1,2-dicarboxylic Anhydride with (3-Bromo-4-pyridyl)triisopropoxytitanium: Synthesis of 5,12-Dimethylindolizino[2,1-g]isoquinoline (Ellipticine Analogue)

Yasuyoshi Miki,* Noriko Nakamura, Ryota Yamakawa, Hajime Hibino, Hiroko Hachiken, and Ko-ichi Matsushita

*Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1, Kowakae, Higashi-Osaka 577-8502, Japan

Abstract

Reaction of indolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)triisopropoxy-titanium gave 2-(3-bromoisonicotinoyl)-3-ethoxycarbonyl--indolizine-1-carboxylic acid as the sole product. The indolizine-1-carboxylic acid could be converted to 5,12-dimethyl-indolizine-[2,1-g]isoquinoline in six steps.