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■ Access to New Cytotoxic Bisindole Alkaloids by a Modified Borch Reductive Amination Process

Guy Lewin,* Corinne Schaeffer, Reynald Hocquemiller, Edgar Jacoby, Stéphane Léonce, Alain Pierré, and Ghanem Atassi

*Laboratoire de Pharmacognosie, Faculté de Pharmacie, av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France

Abstract

A slight modification of the Borch reductive amination method (delayed addition of NaBH₃CN) was applied to an indole aldehyde compound, analog of the natural alkaloid, goniomitine. This reaction led to a series of new cytotoxic bisindole alkaloids with a 1,2,3,4-tetrahydroquinoline bridge.