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Paper | Regular issue | Vol 53, No. 12, 2000, pp.2653-2660
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9009
Studies on Ring Opening Reactions of N-Phenylsulfonyl Substituted Spiro-β-lactamsa

Piero Dalla Croce and Concetta La Rosa*

*Istituto di Chimica Organica, Facoltà di Farmacia, Università degli Studi di Milano, Via Venezian 21, I-20133 Milano, Italy


Ring opening reactions of the spiro-β-lactam 5-benzoyl-3-phenyl-2-phenylsulfonyl-7-thia-2,5-diazaspiro[3.4]octan-1-one (1a) under hydrolytic, reductive and alkylating reaction conditions are reported. There is evidence for the influence of the spiro structure on azetidinone ring reactivity, which is also affected by the presence of the N-phenylsulfonyl group.