Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 53, No. 12, 2000, pp.2775-2780
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9024
Chemoselective Synthesis of Pyrazole Derivatives via β-Enamino Keto Esters

Monica Manferdini, Carlo F. Morelli, and Augusto C. Veronese*

*Dipartimento di Scienze Farmaceutiche , Università di Ferrara, via Fossato di Mortara 17, I-44100, Ferrara, Italy


β-Enamino keto ester (2a) reacts with hydroxylamine to give an isoxazole derivative (3). Compound (2a) reacts with hydrazine, alkyl- and arylhydrazines to give pyrazole derivatives (4a-e) as only reaction products. Methylation of compound (4a) afforded the two isomeric pyrazole derivatives (4b) and (5).