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Note | Regular issue | Vol 53, No. 12, 2000, pp.2775-2780
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9024
Chemoselective Synthesis of Pyrazole Derivatives via β-Enamino Keto Esters

Monica Manferdini, Carlo F. Morelli, and Augusto C. Veronese*

*Dipartimento di Scienze Farmaceutiche , Università di Ferrara, via Fossato di Mortara 17, I-44100, Ferrara, Italy

Abstract

β-Enamino keto ester (2a) reacts with hydroxylamine to give an isoxazole derivative (3). Compound (2a) reacts with hydrazine, alkyl- and arylhydrazines to give pyrazole derivatives (4a-e) as only reaction products. Methylation of compound (4a) afforded the two isomeric pyrazole derivatives (4b) and (5).