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Paper | Regular issue | Vol 55, No. 1, 2001, pp.99-108
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9063
Reactions with N-Chlorosuccinimide of Various 5-Methylimidazo[1,2-a]pyridine Derivatives with an Electron-withdrawing Group Substituted at the 3-Position

Tomomi Ikemoto* and Mitsuhiro Wakimasu

*Chemical Development Laboratory, Takeda Chemical Industries, Ltd., 17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan


Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.