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Paper | Regular issue | Vol 55, No. 1, 2001, pp.109-113
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9067
Microwave-assisted Cyclocondesation under Solvent-free Conditions: Quinoxaline-2,3-dione

Ester Vázquez, Antonio de la Hoz, Nils Elander, Andrés Moreno, and Sharon Stone-Elander*

*Karolinska Pharamcy and Clinical Neurophysiology, Karolinska Hospital and Institute, S-17176 Stockholm, Sweden


Use of monomodal microwave techniques together with solvent-free conditions in the condensation of 1,2-phenylenediamine with diethyl oxalate gives the quinoxaline-2,3-dione in good to high yields after 2-3 min. The method is simple, rapid and avoids prolonged heating with corrosive mineral acids.