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Paper | Regular issue | Vol 55, No. 2, 2001, pp.291-301
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9083
Alkylation of Some Pyrimidine and Purine Derivatives Using Microwave-assisted Methods

Hortensia Rodríguez, Rolando Pérez, Margarita Suárez, Anabel Lam, Nilda Cabrales, and André Loupy*

*Laboratoire des Réactions Sélectives sur Supports, ICMMO, CNRS UMR 8615, Université de Paris-Sud, Bâtiment 410, 91405 Orsay Cedex, France

Abstract

N-Alkylation of adenine (1), guanine (2) and 6-amino-2-thiouracil (3) with different halides has been carried out using microwave-assisted methods in the presence of small amounts of DMF to improve energy transfer and in the case of 3 by coupling with phase transfer catalysis. The results obtained show high yields and selectivities.