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Communication | Special issue | Vol 54, No. 2, 2001, pp.635-638
Published online, 1st January, 1970
DOI: 10.3987/COM-00-S(I)104
Application of Phthalimidine Synthesis with Use of 1,2,3-1H-Benzotriazole and 2-Mercaptoethanol as Dual Synthetic Auxiliaries. 2. Effective Synthesis of Phthalimidines Possessing Bulky Group at 2-Position

Ichiro Takahashi,* Teruki Kawakami, Mako Kimino, Etsushi Hirano, Shigeki Kamimura, Takanori Tamura, Hidehiko Kitajima, Minoru Hatanaka, Hiroyuki Uchida, Akihiko Nomura, and Motohiro Tanaka

*Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Fukui University, Bunkyo, Fukui 910-8507, Japan

Abstract

Potentially bioactive phthalimidines are prepared in fair to good isolated yields by the 1:1 condensation reaction of o-phthalaldehyde with a variety of sterically-hindered primary alkyl amines in the presence of 1,2,3-1H-benzotriazole and 2-mercaptoethanol as dual synthetic auxiliaries.