Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 55, No. 5, 2001, pp.951-960
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9162
A General Large Scale Synthesis of 2-Alkyl-7-methoxyindoles

Bang-Chi Chen,* John Hynes, Jr., Chennagiri R. Pandit, Rulin Zhao, Amanda P. Skoumbourdis, Hong Wu, Joseph E. Sundeen, and Katerina Leftheris*

*Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, NJ 08543-4000, U.S.A.


A general method has been developed for the large scale synthesis of 2-alkyl-7-methoxyindoles and analogs. This method involves an efficient preparation of the key intermediates, 1-(2-nitroaryl)-2-nitroalkanols and 1-(2-nitroaryl)-2-nitroalkenes, and affords 2-alkyl-7-methoxyindoles and analogs in 3 steps with good overall yields.