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Communication | Regular issue | Vol 55, No. 5, 2001, pp.855-859
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9192
Synthesis of Trisubstituted 4-Oxepanones by the Lewis Acid-promoted Three-Component Ring-Expansion Reaction of Cyclopropapyranones, Silyl Enolates and Glyoxylates

Yoshiaki Sugita,* Chikasa Kimura, and Ichiro Yokoe

*Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan


In the presence of SnCl4, cyclopropapyranones easily reacted with silyl enolates and ethyl glyoxylate to give the trisubstituted 4-oxepanones in good yields.