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Paper | Regular issue | Vol 55, No. 6, 2001, pp.1081-1093
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9197
Synthetic Approaches to 4,8-Dimethyl-4’-(N-pyridinium-methyl)-4’,5’-dihydropsoralens and Their Activity against PAM 212 Keratinocytes

Marilyn Whittemore, Ned Heindel,* Christophe Guillon, Thomas McNeel, Robert Rapp, Thomas Mariano, Diane Heck, and Jeffrey Laskin

*Buckman Laboratories International, INC., 1256 Norh McLean Blvd. Memphis, TN 38108, U.S.A.

Abstract

Synthetic approaches to novel 4,8-dimethyl-4’-halomethyl-4’,5’-dihydropsoralens as synthetic precursors to 4,8-dimethyl-4’-(N-pyridiniummethyl)-4’,5’-dihydropsoralens are described. The compounds are potential therapeutic agents for improved psoralen ultraviolet radiation therapy with reduced mutagenicity.