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Communication | Regular issue | Vol 55, No. 6, 2001, pp.1023-1028
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9222
Combinatorial Synthesis of Nikkomycin Analogues on Solid Support

Atsushi Suda, Atsunori Ohta, Masayuki Sudoh, Takuo Tsukuda,* and Nobuo Shimma

*Combination Chemistry Group, Department of Chemsitry, Nippon Roche K.K. Research Center, 200 Kajiwara, kamakura, Kanagawa 247-8530, Japan

Abstract

Synthesis of nikkomycin analogue library by combinatorial synthesis on solid support and evaluation of their enzyme inhibitory activity against Candida albicans chitin synthases are described.