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Note | Regular issue | Vol 55, No. 10, 2001, pp.1927-1935
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9237
Nucleophilic Substitution Reactions of 4,5-Dichloro-2-methyl-6-nitro-2H-pyridazin-3-one

Kyu-Tae Chang, Jeum-Jong Kim, Young-Kook Kim, Ho-Yong Park, Byung-Hwa Hyun, Motoo Shiro, Yong-Jin Yoon, and Woo Song Lee*

*Department of Chemistry, Korea Advanced Institute of Science and Technology, 373-1, Kusung-Dong, Yusung-Gu, Taejon, 305-701, Korea


4,5-Dichloro-2-methyl-6-nitro-2H-pyridazin-3-one (1) reacts with various substituted phenols and 2-mercaptopyrimidine in the presence of NaH or K2CO3 to give 3(2H)-pyridazinones (4, 5a-9a, 5b-9b, and 7c) in high yields. The regiochemistry was confirmed by X-Ray analysis and nOe experiments.