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Note | Regular issue | Vol 55, No. 9, 2001, pp.1813-1816
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9282
A Convenient Route to the Soluble Guanylate Cyclase Activator YC-1 and Its N2 Regioisomer

Patricia A. Fernandez, Tom Bellamy, Marcel Kling, David J. Madge, and David L. Selwood*

*Biological Chemistry, The Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, U.K.


A new route to the soluble guanylate cyclase (sGC) activator YC-1 and its N2 regioisomer has been established with a Mitsunobu mediated N-alkylation as the key step. The route is utilised in the synthesis of a potential photoaffinity label.