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Paper | Regular issue | Vol 55, No. 9, 2001, pp.1747-1757
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9283
One Pot Synthesis of Fused Pyrimidines from 2-[N-(Methylthiothiocarbonyl)amino]acetate

A. Z. M. Shaifullah Chowdhury,* Yasuyuki Shibata, Masatoshi Morita, Kunimitsu Kaya, and Tomoharu Sano

*National Institute for Environmental Studies, Environmental Chemistry Division, 16-2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan


A variety of 3-substituted fused pyrimidines (4a-k) are readily obtained from the 2-amino esters (2a-k) with 2-[N-(methylthiothiocarbonyl)-amino]acetate (1). Condensed imidazo[1,2-c]pyrimidine ring system was also constructed in a one-pot process by reacting heteroaromatic 2-amino nitriles (3a-l) with 1, obtaining a number of novel tri- and tetracyclic compounds (5a-l).