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Paper | Regular issue | Vol 55, No. 11, 2001, pp.2085-2098
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9305
■ Synthesis of Bis-substituted Amidinobenzothiazoles as Potential Anti-HIV Agents

Livio Racane, Vesna Tralic-Kulenovic, Lelja Fiser-Jakic, David W. Boykin, and Grace Karminski-Zamola*

*Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 20, P.O Box 177, HR-10000 Zagreb. Croatia

Abstract

In the multistep syntheses of the title compounds we obtained some new cyano-substituted heterocycles (1a, 1b, 2a, and 2b) as intermediates. Starting from dinitriles (2a and 2b) as well as from two formerly prepared dinitriles, substituted bisamidines (3a, 3b, 5a, 5b, 7a, and 7b) and amidino dihydrochlorides (4a, 4b, 6a, 6b, 8a, 8b, 9a, and 9b) have been synthesized.