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Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Paper | Regular issue | Vol 55, No. 11, 2001, pp.2099-2108
Published online, 1st January, 1970■ A Facile Entry to Bicyclic Systems from L-Glutamic Acid
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9308
■ A Facile Entry to Bicyclic Systems from L-Glutamic Acid
Bryan A. Frieman, Charles W. Bock, and Krishna L. Bhat*
*Department of Chemistry, School of Science and Health, Philadelphia University, School House Lane & Henry Avenue,Philadelphia, PA 19144-5497, U.S.A.
Abstract
An efficient synthesis of bicyclic heterocycles has been realized from L-glutamic acid. The key step is the construction of the pyrrole ring in a single step, using tosylmethyl isocyanide (TosMIC) methodology. Structures of reaction intermediates and final products were investigated using density functional theory calculations.
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