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Communication | Regular issue | Vol 55, No. 11, 2001, pp.2055-2057
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9334
Simple Synthesis of 1,3,4,5a,6,10b,11,11a-Octahydro-2H-pyrazino[1’,2’:1,5]pyrrolo[2,3-b]indole Derivatives Based on 1-Hydroxyindole Chemistry

Yoshikazu Fukui and Masanori Somei*

*Kanazawa University, Faculty of Pharmaceutical Sciences, 13-1 Takara-machi, Kanazawa 920-0934, Japan


3-Substituted (3S,6S)-6-(1-hydroxyindol-3-ylmethyl)-2,5-piperazine- diones are prepared for the first time. They are shown to be suitable intermediates for the synthesis of 3,10b-disubstituted (3S,5aR,10bS,11aS)-1,3,4,5a,6,10b,11, 11a-octahydro-2H-pyrazino[1’,2’:1,5]pyrrolo[2,3-b]indole-1,4-dione derivatives.