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Communication | Regular issue | Vol 57, No. 1, 2002, pp.1-4
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9362
Synthesis of Ethyl 1,2,3,4-Tetrahydroisoquinoline-1-carboxylates by Pictet-Spengler Condensation Using Phenyliodine(III) Bis(trifluoroacetate)

Iou-Jiun Kang, Huey-Min Wang, Chien-Hsing Su, and Ling-Ching Chen*

*Graduate Institute of Pharmaceutical Sciences , Kaohsiung Medical University,100 Shih Chen 1st Rd., Kaohsiung 80708, Taiwan, R.O.C.


Abstract—The reaction of N-sulfonyl-β-phenethylamines with ethyl methylthioacetate using phenyliodine(III) bis(trifluoroacetate) gives moderate to good yields of the corresponding ethyl 1,2,3,4-tetrahydroisoquinoline-1-carboxylates.